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SB 265610
CAS No. 211096-49-0
SB 265610( SB265610 | SB-265610 )
Catalog No. M13354 CAS No. 211096-49-0
A potent, selective, reversible CXCR2 antagonist with with Kd of 3.48 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 110 | In Stock |
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| 10MG | 177 | In Stock |
|
| 25MG | 356 | In Stock |
|
| 50MG | 530 | In Stock |
|
| 100MG | 759 | In Stock |
|
| 500MG | 1557 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSB 265610
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, reversible CXCR2 antagonist with with Kd of 3.48 nM.
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DescriptionA potent, selective, reversible CXCR2 antagonist with with Kd of 3.48 nM; inhibits protein nitration induced by hyperoxia, reduces radical formation in hyperoxia-exposed newborn rat lung; also induces G1 arrest, ans shows anti-proliferative activity in in IL8-rich tumor microenvironments.
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In Vitro——
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In VivoAnimal Model:MMTV-PyVmT/Tgfbr2MGKO and MMTV-PyVmT/Tgfbr2flox/flox tumors from donor mice Dosage:2 mg/kg/day Administration:Intraperitoneal injection; daily; for two weeks Result:Significantly inhibited the recruitment of Gr-1+CD11b+ cells to the mammary adenocarcinoma.
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SynonymsSB265610 | SB-265610
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PathwayGPCR/G Protein
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TargetChemokine Receptor
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RecptorChemokine Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number211096-49-0
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Formula Weight357.16
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Molecular FormulaC14H9BrN6O
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Purity>98% (HPLC)
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Solubility100 mM in DMSO
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SMILESO=C(NC1=C2N=NNC2=C(C#N)C=C1)NC3=CC=CC=C3Br
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Chemical NameN-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. de Kruijf P, et al. J Pharmacol Exp Ther. 2009 May;329(2):783-90.
2. Bradley ME, et al. Br J Pharmacol. 2009 Sep;158(1):328-38.
3. de Kruijf P, et al. Mol Pharmacol. 2011 Dec;80(6):1108-18.
4. Goda AE, et al. Anticancer Res. 2015 Jun;35(6):3235-43.
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